Streptomycin resistance in mycobacteria
نویسندگان
چکیده
منابع مشابه
Transduction of isoniazid susceptibility-resistance and streptomycin resistance in mycobacteria.
Transduction of resistance to isoniazid and streptomycin as well as susceptibility to isoniazid in Mycobacterium smegmatis SN2 has been demonstrated. A method has been described for the selection of isoniazid-susceptible variants after transduction of susceptibility.
متن کاملA Quantitative Analysis of the Resistance of Mycobacteria to Streptomycin.
The rapid rate at which bacteria develop resistance to streptomycin has been demonstrated in vitro and in vivo. Quantitative studies have been made of certain species of non-acid-fast organisms which give rise to streptomycin-resistant variants (Klein, 1947; Alexander and Leidy, 1947; Klein and Kimmelman, 1946). These investigations show that small numbers of resistant cells are present in susc...
متن کاملStreptomycin resistance in a streptomycin-producing microorganism.
Cell-free extracts of Streptomyces bikiniensis contain an adenosine 5'-triphosphate-dependent kinase which inactivates streptomycin (Sm) and dihydrostreptomycin by phosphorylation. The products have been identified as streptomycin 6-phosphate and dihydrostreptomycin 6-phosphate. Activity was not present in logarithmic-phase cells, which were susceptible to 25 mug of Sm per ml. In stationary-pha...
متن کاملResistance factor-mediated streptomycin resistance.
Resistance (R) factor-mediated streptomycin (Sm) resistance differs from classical, high-level, chromosome-borne Sm resistance in its dominance over sensitivity and in the level of its effectiveness (in Escherichia coli approximately 25 mug/ml versus >2,000 mug/ml). In addition, an R factor-containing strain, unlike high-level Sm-resistant bacteria, showed an inoculum effect with respect to its...
متن کاملThe inhibition by streptomycin of adaptive enzyme formation in mycobacteria.
A number of Mycobacteria oxidize benzoic acid and some can use it as the sole source of carbon (1). Upon addition of benzoic acid to suspensions of washed organisms in the Warburg vessel its oxidation proceeds slowly for 30 to 60 minutes, then very rapidly until about half the amount of oxygen for complete combustion is taken up. The rate then parallels that of the autorespiration. It was thoug...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1994
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.38.2.238